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目的:了解糖尿病母亲婴儿的智能发育水平,探讨妊娠期糖尿病对婴儿智能发育的影响,以改善其远期预后。方法:随机选择在该中心就诊的78例糖尿病母亲婴儿作为观察组,48例正常婴儿为对照组;运用新生儿神经行为测定(NBNA)法测定两组儿童的行为能力及神经发育状况;运用盖泽尔(Gesell)发育量表对两组儿童进行智力发育的测定,随访至24月龄。结果:观察组其NBNA评分明显低于对照组(P<0.01);观察组患儿2月龄、6月龄及12月龄发育商(DQ)均明显低于对照组(P<0.01),但24月龄发育商与对照组无统计学差异(P>0.05)。结论:妊娠期糖尿病可能影响后代智能发育,应加强妊娠期糖尿病的孕期管理,严格控制血糖,改善糖尿病母亲婴儿的远期预后。
Objective: To understand the intelligence development of infants with diabetic mothers and to explore the effect of gestational diabetes on the infant’s intellectual development in order to improve their long-term prognosis. Methods: Seventy-eight cases of diabetic mothers treated in the center were selected as the observation group and 48 normal infants as the control group. The behavioral and neurological status of the two groups were measured by neonatal neurobehavior test (NBNA) The Gesell Scale was used to measure the mental development of two groups of children, up to 24 months of age. Results: The NBNA score of the observation group was significantly lower than that of the control group (P <0.01). The 2-month, 6-month and 12-month old DQ of the observation group were significantly lower than that of the control group (P <0.01) However, there was no significant difference between 24-month-old developmental and control groups (P> 0.05). Conclusion: Gestational diabetes mellitus may affect the intelligence development of offspring. Pregnancy management of gestational diabetes mellitus should be strengthened, blood glucose should be controlled strictly and the long-term prognosis of diabetic infants should be improved.