药物代谢性相互作用主要发生在肝脏,其代谢媒体最重要的是细胞色素P450混合功能氧化酶系统,简称药酶或P450酶。该酶的作用主要是将药分解代谢成无活性、水溶性的小分子物质以便于排出体外。当药酶的活性受到抑制则药物代谢减少,血药浓度增高,药物作用增强。反之,作用减弱。药物 Drug metabolism interaction occurs mainly in the liver, the metabolic media is the most important cytochrome P450 mixed-function oxidase system, referred to as drug enzyme or P450 enzyme. The role of the enzyme is mainly catabolism of drugs into inactive, water-soluble small molecules to facilitate excretion. When the enzyme activity is inhibited, the drug metabolism is reduced, the blood concentration is increased, and the drug effect is enhanced. On the contrary, the effect weakened. drug