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目的了解SARS感染的危险因素。方法选择2002年11月16日至2003年6月30日广东省报告的符合“卫生部《传染性非典型肺炎临床诊断标准(试行)》”的病例,在病例的邻居中选择与病例年龄相差不超过5岁,性别相同,无接触史且无发病者作为对照,采用回顾性调查方法,调查内容包括一般情况、流行病学史、家庭环境、工作场所环境、个人饮食和卫生情况。采用单因素和多因素Logistic回归分析方法进行比较。结果共调查病例809例、对照331例。多因素条件Logistic回归分析结果表明,发病前20 d有外县旅行史(OR=1.82,95%CI为1.05~3.17)、去过医院(OR=1.59,95%CI为1.06~2.39),有SARS/可疑SARS病例接触史(OR=1.66,95%CI为1.33~2.08)和有动物接触史(OR=1.53,95%CI为1.05~2.24)是SARS感染的危险因素,工作场所通风良好(OR=0.56,95%CI为0.41~0.76)是SARS感染的保护因素。结论接触SARS或可疑SARS病例、去过医院、有外县旅行史和有接触动物史是SARS感染的危险因素。
Objective To understand the risk factors of SARS infection. Methods From November 16, 2002 to June 30, 2003, the cases reported by Guangdong Province in line with the “Clinical Diagnostic Criteria for SARS (Trial)” of the Ministry of Health were selected and their ages in the neighbors were selected Not more than 5 years of age, same sex, history of non-contact and no morbidity as a control, using a retrospective survey methodology. The survey included general information, epidemiological history, family environment, workplace environment, personal diet and hygiene. Single factor and multivariate Logistic regression analysis were used to compare. Results A total of 809 cases were investigated and 331 cases were controlled. Multivariate conditional Logistic regression analysis showed that there was a history of traveling outside counties (OR = 1.82, 95% CI 1.05-3.17) and hospital visits (OR = 1.59, 95% CI 1.06-2.39) The history of exposure to SARS / suspicious SARS (OR = 1.66, 95% CI 1.33 to 2.08) and history of exposure to animals (OR = 1.53, 95% CI 1.05-2.24) were risk factors for SARS and were well ventilated in the workplace OR = 0.56, 95% CI 0.41 to 0.76) is a protective factor against SARS infection. Conclusions Exposure to SARS or suspicious cases of SARS, hospital trips, history of contact with other counties and history of contact with animals is a risk factor for SARS infection.