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目的探讨血管紧张素Ⅰ转化酶（ＡＣＥ）基因第１６内含子插入／丢失多态性与妊娠高血压综合征（简称妊高征）的关系。方法应用聚合酶链反应，检测６０例妊高征患者及对照组７６例正常孕妇的ＡＣＥ基因中第１６内含子是否有Ａｌｕ重复结构存在。结果６０例妊高征患者中ＡＣＥ基因Ｉ型和ＤＤ型频率分别为１５％（９／６０）和６５％（３９／６０），而７６例正常晚期妊娠妇女中则分别为５０％（３８／７６）和１０．５％（８／７６）。妊高征组的缺失型（Ｄ型）ＡＣＥ等位基因出现频率为０．７５，高于对照组的０．３０８，差异有显著性（Ｐ＜０．０１）。结论提示Ｉ型基因是妊高征的保护性基因，ＤＤ型基因是妊高征的易感基因，ＡＣＥ基因的缺失多态性（ＤＤ）可能与妊高征的发病有关。
Objective To investigate the relationship between the 16th intron insertion / deletion polymorphism of angiotensin Ⅰ converting enzyme (ACE) gene and pregnancy induced hypertension syndrome (PIH). Methods Polymerase chain reaction (PCR) was used to detect the existence of Alu repeats in the 16th intron of ACE gene in 76 pregnant women with PIH and 76 normal controls. Results The frequency of ACE genotypes I and DD in 15 patients with PIH was 15% (9/60) and 65% (39/60) respectively, while in 76 normal pregnant women, 50% (38 / 76) and 10.5% (8/76). In the PIH group, the deletion type (D) ACE allele frequency was 0.75, which was significantly higher than that of the control group (0.308) (P <0.01). The results suggest that type I gene is a protective gene for PIH. DD type is a predisposing gene for PIH. The deletion polymorphism of ACE gene may be related to the pathogenesis of PIH.