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目的客观公正地评价甘肃省崇信县预防接种副反应的发生率,为制定预防接种副反应策略提供科学依据。方法对报告的预防接种副反应病例进行统计、分析。结果 2003~2010年崇信县人民医院公共卫生科使用疫苗9种,接种疫苗41 128剂次,共监测报告29例接种副反应病例,报告发生率7.05/万(29/41 128),其中:一般副反应27例,报告发生率6.57/万(27/41 128);异常反应2例,报告发生率0.49/万(2/41 128)。发生预防接种副反应的主要疫苗是:乙脑减毒活疫苗,发生率最高,为63.83/万(6/940);其次为百白破三联疫苗和无细胞DPT,分别为36.91/万(11/2980)和26.6/万(5/1 880)。基础免疫儿童(0～1岁)占89.66%,接种后0～3 d内发生副反应的占93.10%,发热病例占72.41%,是预防接种副反应的主要特征。结论异常反应发生率相对很低,说明免疫规划疫苗接种是安全的。
Objective To evaluate objectively and fairly the incidence of adverse reactions in Chongxin County, Gansu Province, and to provide a scientific basis for formulating the strategy of side effects of vaccination. Methods The reported cases of vaccination side effects were statistically analyzed. Results From 2003 to 2010, 9 vaccines and 41 128 doses of vaccines were administered to the public health department of Chongxin County People’s Hospital. A total of 29 cases of adverse reactions were reported, with a reported incidence of 7.05 / million (29/41 128), of which: There were 27 cases of general side effects, with a reported incidence of 6.57 / million (27/41 128); 2 cases of abnormal reaction, the incidence of the report was 0.49 / (2/41 128). The main vaccines against side effects of vaccination were: live attenuated JE vaccine with the highest incidence of 63.83 / million (6/940); followed by diphtheria triple immunization (TRP) and cell free DPT (36.91 / / 2980) and 26.6 / million (5/1 880). The basic immunization children (0-1 years old) accounted for 89.66%, 0-3 days after inoculation side reactions accounted for 93.10%, fever cases accounted for 72.41%, is the main feature of vaccination side effects. Conclusions The incidence of abnormal reaction is relatively low, indicating that immunization vaccination is safe.