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目的:探讨血小板减少症患者血清促血小板生成素(TPO)和白细胞介素-11(IL-11)水平及其与外周血小板计数之间的关系。方法:141例患者分为ITP组、血液肿瘤组和实体肿瘤组3组,应用双抗夹心ABC-ELISA法测定TPO、IL-11,同时用自动血细胞仪测定其血小板数,以30例健康人为正常对照。结果:ITP组、血液肿瘤组和实体肿瘤组的血清TPO水平分别为(130.5±88.3)pg/ml、(103.5±83.9)pg/ml和(148.1±92.5)pg/ml,各组与对照组比较差异无统计学意义。ITP组、血液肿瘤组和实体肿瘤组的血清IL-11水平分别为(46.8±35.8)pg/ml、(40.3±24.7)pg/ml和(44.5±22.3)pg/ml;对照组则为(36.0±18.7)pg/ml。ITP组和实体肿瘤组血清IL-11水平明显高于对照组(均P<0.05)。结论:不同原因血小板减少症患者血清TPO、IL-11水平不一致,检测其有助于了解不同原因血小板减少的可能机制和指导临床治疗。
Objective: To investigate the relationship between serum platelet-thrombopoietin (TPO) and interleukin-11 (IL-11) levels and peripheral platelet count in patients with thrombocytopenia. Methods: One hundred and seventy-one patients were divided into three groups: ITP group, hematologic tumor group and solid tumor group. TPO and IL-11 levels were determined by ABC-ELISA. Meanwhile, the number of platelets was measured by automated hematology analyzer. Normal control. Results: The levels of serum TPO in ITP group, hematological tumor group and solid tumor group were (130.5 ± 88.3) pg / ml, (103.5 ± 83.9) pg / ml and (148.1 ± 92.5) pg / ml respectively) The difference was not statistically significant. Serum levels of IL-11 in ITP group, hematological tumor group and solid tumor group were (46.8 ± 35.8) pg / ml, (40.3 ± 24.7) pg / ml and (44.5 ± 22.3) pg / ml respectively; 36.0 ± 18.7) pg / ml. Serum levels of IL-11 in ITP group and solid tumor group were significantly higher than those in control group (all P <0.05). Conclusion: The levels of serum TPO and IL-11 in patients with different causes of thrombocytopenia are inconsistent. It is helpful to understand the possible mechanism of thrombocytopenia in different causes and guide the clinical treatment.