Claudin蛋白是细胞间紧密连接蛋白的主要结构之一,其表达具有组织特异性,在维持细胞极性和紧密连接屏障功能方面起着重要作用。Claudin蛋白的异常表达与恶性肿瘤的发生和发展有着密切关系,多种途径可能参与了Claudins表达的调节。研究claudins在生理、病理状态下的改变,有助于对相关肿瘤进行诊断、针对性治疗和判断预后。Claudins为肿瘤的诊断和治疗提供了一种新思路。 Claudin protein is one of the main structures of tight junction protein in cells. Its expression is tissue-specific and plays an important role in maintaining cell polarity and tight junction barrier function. The abnormal expression of Claudin protein is closely related to the occurrence and development of malignant tumors. A variety of pathways may be involved in the regulation of Claudins expression. Research claudins in physiological and pathological changes, help to diagnose related tumors, targeted treatment and prognosis. Claudins provides a new idea for the diagnosis and treatment of tumors.