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分子生物学的研究表明在细胞发生恶性转化的过程中Ｇ１期细胞周期调控因子起着关键性的作用。近年与胶质瘤相关的研究显示,Ｃｙｃｌｉｎ Ｄ１和Ｃｙｃｌｉｎ Ｅ等起正调节作用的因子在胶质瘤中存在过表达现象,而起负调节作用的Ｐ１５、Ｐ１６基因在胶质瘤中多表现为以纯合性缺失为主的变异,Ｐ２１、Ｐ２７基因虽无明显变异,却以量的方式在胶质瘤的发生中发挥作用。这些Ｇ期调控因子均被证明与胶质瘤的恶性程度和细胞增殖活性相关,既是鉴别良恶性和判断预后的指标,又是基因治疗的候选靶基因。
Molecular biology studies have shown that G1 phase cell cycle regulators play a key role in the malignant transformation of cells. In recent years, glioma-related studies have shown that Cyclin D1 and Cyclin E and other factors play a positive role in the regulation of glioma over-expression, and negatively regulate the P15, P16 gene expression in gliomas more In homozygous deletion-dominant variation, the P21 and P27 genes play a role in the development of glioma in a quantitative manner, although there is no obvious variation. These G regulatory factors have been shown to be associated with the degree of glioma malignancy and cell proliferation activity, both to identify benign and malignant and prognostic indicators, but also gene therapy candidate target gene.