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本文应用放射免疫法测定了４０例肺心病患者和２１例正常健康人的血清和尿β２－微球蛋白浓度。结果表明：肺心病患者血尿素氮、血肌酐与正常健康人对照组比较无显著性差异（ｐ＞０．０５），而血、尿β２－微球蛋白有非常显著性差异（ｐ＜０．０１）．肺心病心衰组血、尿β２－微球蛋白与肺心病心功能代偿组比较有显著性差异（ｐ＜０．０１）。我们认为血、尿β２－微球蛋白测定可作为肺心病患者的常规检测项目，对及早发现心、肾功能损害，保护肾功能，判断疗效、预后等有一定实用价值。
In this paper, serum and urinary β2-microglobulin concentrations in 40 patients with cor pulmonale and 21 normal controls were measured by radioimmunoassay. The results showed that blood urea nitrogen and serum creatinine in patients with pulmonary heart disease showed no significant difference (p> 0.05) compared with those in healthy controls, but there were significant differences in blood and urine β2-microglobulin (p <0. 01). Pulmonary heart disease, heart failure group of blood, urinary β2-microglobulin and pulmonary heart disease compensation group had significant differences (p <0.01). We believe that blood and urine β2-microglobulin determination can be used as a routine test for patients with cor pulmonale. It is of practical value for early detection of heart and kidney damage, protection of renal function, judgment of curative effect and prognosis.