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自人们发现 2 -甲酰吡啶缩氨基硫脲具有抗肿瘤活性以来 ,缩氨基硫脲、缩氨基脲等腙类化合物的抗癌活性已有诸多报道 ,作为主族元素的 Sn也有杀伤恶性肿瘤的作用 ,因而合成其缩氨基硫脲的金属配合物 ,利用其协同作用研究它们的抗肿瘤作用 ,是十分有意义的工作 .1 实验部分1.1
Since the discovery of the antitumor activity of 2-formylpyridine thiosemicarbazone, the anticancer activity of hydrazones such as thiosemicarbazone and semicarbazone has been reported. As a main group of elements, Sn has also been shown to kill malignant tumors Therefore, it is very meaningful to synthesize the metal complexes of thiosemicarbazone and to study their anti-tumor effect by their synergistic effect.1 Experimental 1.1