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采用Ｕ型管电泳法研究作为药物载体的聚氰基丙烯酸正丁酯毫微球的电学特性。研究表明：聚氰基丙烯酸正丁酯毫微球荷负电；其表面动电位与稳定剂浓度和ｐＨ值呈正相关；和载体材料的加量呈负相关；稳定剂和表面活性剂种类对表面动电位有影响；离子强度的影响呈非线性关系；而实验条件下电解质的影响不明显；模型药物（庆大霉素）的加入可使表面动电位下降。本研究为载药毫微球制备工艺的建立奠定了基础。
Study on the Electrical Properties of Polybutylcyanoacrylate Nanospheres as Drug Carrier by U - tube Electrophoresis. The results showed that the n-butyl polycyanoacrylate nanoparticles were negatively charged; their surface potentials were positively correlated with the concentrations of stabilizer and pH; negatively correlated with the amount of carrier materials; and the types of stabilizers and surfactants were negative Potentials influence; ionic strength has a nonlinear relationship; while under the experimental conditions, the effect of electrolyte is not obvious; model drug (gentamicin) can reduce the surface potentiodynamic potential. This study laid the foundation for the establishment of drug-loaded nanosphere preparation technology.