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患前列腺癌施行两侧睾丸切除术后的热潮红不常见,可是一旦发生则常很麻烦也很难治。作者评价环丙氯地孕酮(cyproterone acetate,一种抗雄激素也抑制促性腺激素释放)治疗睾丸切除术后热潮红的效果。 12例睾丸切除术后热潮红病人(平均年龄67.4岁,63.5～72.5岁),各例接受环丙氯地孕酮(100mg,3/日)治疗3周,安慰剂3周。在最初3周,8例接受环丙氯地孕酮,4例安慰剂。作者对每例病人在各次治疗期间计算平均每天热潮红次数。环丙氯地孕酮治疗的病人热潮红出现率统计学上有明显减少(P<0.001)。
Prostate cancer on both sides of the orchidectomy after the hot flush is not common, but in the event is often very troublesome and difficult to cure. The authors evaluate the effect of cyproterone acetate (an antiandrogen that inhibits gonadotropin release) in the treatment of hot flashes after orchiectomy. Twelve patients undergoing orchidectomy (mean age, 67.4 years, 63.5-72.5 years) received either cyclosporin (100 mg, 3 / day) for 3 weeks or placebo for 3 weeks. In the first 3 weeks, 8 received cyproterone and 4 received placebo. The authors calculated the average number of hot flashes per treatment during each treatment. The incidence of hot flashes in patients treated with cyproterone was statistically significantly reduced (P <0.001).