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目的:观察阿莫西林联合甲硝唑治疗种植体周围炎临床效果及对基质金属蛋白酶8（MMP-8）、肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β）的影响。方法:选择下沙医院2017年1月至2019年12月收治的种植体周围炎患者64例为观察对象，采用随机数字表法将其分为对照组（32例）和观察组（32例）。对照组给予甲硝唑治疗，观察组给予阿莫西林联合甲硝唑治疗，比较两组临床疗效、牙周袋深度（PD）、附着水平（CAL）、出血指数（SBI）、牙菌斑指数（PLI）、MMP-8、TNF-α、IL-1β水平及不良反应发生率，并分析PD、CAL、SBI、PLI水平与MMP-8、TNF-α、IL-1β的相关性。结果:观察组治疗有效率高于对照组［93.75％（30/32）比75.00％（24/32）］（χn 2=4.267，n P<0.05）。治疗后观察组PD［（3.02±0.24）mm］、CAL［（1.70±0.14）mm］、SBI［（11.54±3.26）％］、PLI［（0.87±0.11）］水平均显著低于对照组［（4.47±1.37）mm、（3.77±1.06）mm、（18.84±5.11）％、（1.12±0.15）］，差异均有统计学意义（n t=5.897、10.952、6.813、7.603，均n P<0.001）；治疗后观察组血清MMP-8［（0.78±0.23）μg/L］、TNF-α［（71.24±10.33）μg/L］、IL-1β［（1.20±0.14）μg/L］水平均低于对照组［（1.12±0.35）μg/L、（113.28±15.73）μg/L、（2.55±1.02）μg/L］，差异均有统计学意义（n t=4.592、12.637、7.417，均n P<0.001）。Spearman相关系数分析显示，PD、CAL、SBI、PLI水平与MMP-8、TNF-α、IL-1β均呈正相关（均n P<0.05）。n 结论:阿莫西林联合甲硝唑治疗种植体周围炎临床效果显著，可促进菌斑消退，减轻炎性反应，具有一定的临床推广价值。“,”Objective:To investigate the clinical efficacy of amoxicillin combined with metronidazole in the treatment of peri-implantitis and its effect on serum matrix metalloproteinase-8 (MMP-8), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels.Methods:Sixty-four patients with peri-implantitis who received treatment from January 2017 to December 2019 in Xiasha Hospital, SiR Run Run Shaw Hospital, Zhejiang University School of Medicine were included in this study. They were randomly assigned to receive treatment with metronidazole (control group, n n = 32) or amoxicillin combined with metronidazole (observation group, n n = 32). Clinical efficacy, periodontal pocket depth (PD), clinical attachment level (CAL), sulcus bleeding index (SBI), plaque index (PLI), matrix metalloproteinase-8 (MMP-8), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) levels and the incidence of adverse reactions were compared between the control and observation groups. PD, CAL, SBI and PLI were correlated with MMP-8, TNF-α and IL-1β levels.n Results:The clinical efficacy in the observation group was significantly higher than that in the control group [93.75% (30/32) n vs. 75.00% (24/32), n χ2 = 4.267, n P < 0.05]. After treatment, PD [(3.02 ± 0.24) mm], CAL [(1.70 ± 0.14) mm], SBI [(11.54 ± 3.26)%], PLI (0.87 ± 0.11) in the observation group were significantly lower than those in the control group [(4.47 ± 1.37) mm, (3.77 ± 1.06) mm, (18.84 ± 5.11)%, (1.12 ± 0.15), n t = 5.897, 10.952, 6.813, 7.603, all n P < 0.01]. After treatment, serum MMP-8 [(0.78 ± 0.23) μg/L], TNF-α [(71.24 ± 10.33) μg/L], IL-1β [(1.20 ± 0.14) μg/L] levels in the observation group were significantly lower compared with the control group [(1.12 ± 0.35) μg/L, (113.28 ± 15.73) μg/L, (2.55 ± 1.02) μg/L, n t = 4.592, 12.637, 7.417, all n P < 0.01]. Spearman correlation coefficient analysis showed that PD, CAL, SBI and PLI were positively correlated with serum MMP-8, TNF-α and IL-1β levels (all n P < 0.01).n Conclusion:Amoxicillin combined with metronidazole is highly effective in the treatment of peri-implantitis because it can promote plaque regression, reduce inflammatory reaction, and has a certain clinical promotion value.