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目的研究我国汉族SARS康复患者发生肺间质纤维化及股骨头缺血性坏死与HLA-A基因多态性的相关性。方法应用PCR-SBT的研究方法对53例SARS患者HLA-A位点进行基因分型,直接计数法进行基因频数计算,采用卡方检验进行资料比较。结果康复SARS患者中,按照是否发生肺间质纤维化来分,未见HLA-A位点的等位基因频率分布在两组人群间,差异有统计学意义(P>0.05);同时,按照是否发生股骨头缺血性坏死来分,未见HLA-A位点的等位基因频率分布在两组人群间,差异有统计学意义(P>0.05)。结论HLA-A基因可能与SARS患者发生肺间质纤维化及股骨头缺血性坏死无关。
Objective To study the correlation between HLA-A polymorphisms and pulmonary interstitial fibrosis and avascular necrosis of the femoral head in Chinese SARS-rehabilitated patients. Methods PCR-SBT method was used to genotype HLA-A locus in 53 patients with SARS. The direct counting method was used to calculate the frequency of HLA-A loci. The data were compared by chi-square test. Results There was no significant difference in allele frequencies of HLA-A loci between the two groups according to whether pulmonary interstitial fibrosis occurred or not in rehabilitation SARS patients (P> 0.05). At the same time, The frequency of HLA-A alleles was not significantly different between the two groups (P> 0.05). Conclusion The HLA-A gene may not be associated with pulmonary fibrosis and avascular necrosis of the femoral head in patients with SARS.