采用正交试验法，以投料药材的干粉得率和干粉的总蒽醌含量为考核指标，对肝毒净颗粒剂所采用的“提取—浓缩—喷雾干燥”工艺与药材煎煮时间，煎煮次数，加水量，欲干燥药物清膏的相对密度，喷雾干燥器进风温度及出风温度等主要工艺因素的相关性进行研究，为优选该制剂的生产工艺提供依据。 Orthogonal test was used to evaluate the dry powder yield and total anthraquinone content of the medicinal materials. The “extraction-concentration-spray-drying” process and the decoction time of medicinal materials, The number of added water, the relative density of the drug to be dried, the inlet air temperature of the spray dryer and the outlet air temperature were studied. The results provided the basis for the optimization of the production process of the preparation.