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目的:探讨益气化瘀汤对早期糖尿病肾病(DN)血细胞因子的影响。方法:将105例早期糖尿病肾病随机分为对照组(50例)与观察组(55例)。对照组用洛汀新片:10mg/次,1次/日,口服;观察组在对照组基础上加用益气化瘀汤每天1剂,8周为1疗程。治疗前后检测血白介素(IL-8)、IL-18、肿瘤生长因子a(TNF-a)水平。并附50例健康对照组。结果:两组治疗前炎性细胞因子比较差异无统计学意义(P>0.05),但明显高于健康组(P<0.01);观察组自身治疗前后细胞因子水平比较均明显下降(P<0.01);治疗后两组比较,差异有统计学意义(P<0.01)。结论:IL-8、IL-18、TNF-a与糖尿病肾病的发生发展相关,益气化瘀汤可能在抑制早期糖尿病肾病发展过程中起着积极的作用。
Objective: To investigate the effect of Yiqi Huayu decoction on blood cytokines in patients with early diabetic nephropathy (DN). Methods: 105 cases of early diabetic nephropathy were randomly divided into control group (50 cases) and observation group (55 cases). Control group with Lotensin tablets: 10mg / time, 1 times / day, oral; observation group in the control group based on the use of Yiqi Huayu Tang 1 day, 8 weeks for a course of treatment. Serum levels of interleukin (IL-8), IL-18 and tumor growth factor a (TNF-a) were measured before and after treatment. With 50 cases of healthy control group. Results: There was no significant difference in inflammatory cytokines between the two groups before treatment (P> 0.05), but significantly higher than the healthy group (P <0.01). The levels of cytokines in the observation group decreased significantly before and after treatment (P <0.01) ); After treatment, the difference between the two groups was statistically significant (P <0.01). Conclusion: IL-8, IL-18 and TNF-a are associated with the occurrence and development of diabetic nephropathy. Yiqi Huayu Decoction may play an active role in inhibiting the development of early diabetic nephropathy.