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目的调查内分泌科及心内科门诊中糖尿病合并高血压患者微量白蛋白尿(MA)检出率。方法多中心连续收集2型糖尿病合并高血压患者共2473例,采用统一调查表记录患者糖尿病、高血压控制情况及相关并发症,测量血压。采用 Micral-Ⅱ试纸半定量比色法筛查尿微量白蛋白。结果 2型糖尿病合并高血压患者 MA 的检出率为42.9%,大量白蛋白尿检出率17.0%。多因素回归分析显示,患者年龄、收缩压水平、空腹血糖水平以及 BMI 与糖尿病合并高血压患者 MA 的发生独立相关;除上述因素外,尚有糖尿病病程、应用利尿剂与大量白蛋白尿的发生独立相关。结论在2型糖尿病合并高血压患者中 MA 检出率极高,MA 筛查及强力降压治疗甚为重要。
Objective To investigate the detection rate of microalbuminuria (MA) in patients with diabetes mellitus and hypertension in the Department of Endocrinology and Cardiology. Methods A total of 2473 patients with type 2 diabetes mellitus complicated with hypertension were collected in multicentre. The patients’ diabetes, hypertension control and related complications were recorded by a unified questionnaire. Blood pressure was measured. Urine microalbumin was screened by semi-quantitative Micrac-Ⅱ test strip. Results The detection rate of MA in type 2 diabetic patients with hypertension was 42.9%, and the detection rate of massive albuminuria was 17.0%. Multivariate regression analysis showed that patients’ age, systolic blood pressure, fasting blood glucose level and BMI were independently associated with the occurrence of MA in diabetic patients with hypertension. In addition to the above factors, there was diabetes course, diuretics and massive albuminuria Independently related. Conclusion The detection rate of MA is very high in patients with type 2 diabetes mellitus complicated with hypertension, MA screening and intensive antihypertensive treatment are very important.