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真核生物细胞周期失控是细胞增殖过度及癌变的重要原因。细胞周期蛋白依赖性激酶 (ｃｙｃｌｉｎ -ｄｅｐｅｎｄｅｎｔｋｉｎａｓｅ ,ＣＤＫｓ)是细胞周期调控的的核心装置 ,调节多种关键底物的磷酸化 ,激发Ｇ1—Ｓ期、Ｇ2 —Ｍ期转换。即细胞周期调控有赖于ＣＤＫｓ的活化。细
Eukaryotic cell cycle out of control cell proliferation and cancer is an important reason. Cyclin-dependent kinases (CDKs) are the core components of cell cycle regulation, which regulate the phosphorylation of many key substrates and stimulate G1-S phase and G2-M phase transition. That is, cell cycle regulation depends on the activation of CDKs. fine