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卵巢癌是致死性很高的妇科肿瘤之一,虽然新的化疗方案改善了患者的5年生存率,但卵巢癌患者的总体存活率一直没有太大改善,人们试图通过分子病因、分子标志及分子靶点等多方面取得突破。Shih等[1]在11号染色体长臂1区3带5亚带发现了13个扩增基因,接着他们在该亚带有基因扩增的10例高度恶性卵巢癌组织中发现,以上扩增基因中空间重组因子1/乙型肝炎病毒X相关蛋白(Rsf-1/HBXAP)是惟一一个在所有被测卵巢癌组织中均有表达的癌基因。
Ovarian cancer is one of the most lethal gynecologic cancers. Although new chemotherapeutic regimens have improved the 5-year survival rate of patients, the overall survival rate of ovarian cancer patients has not been greatly improved. People try to find out the molecular etiology, molecular markers and Molecular targets and many other breakthroughs. Shih et al [1] found 13 amplified genes in zone 1, zone 3, and zone 5 of the long arm of chromosome 11, and they found that in the 10 highly malignant ovarian cancers with this gene subpopulation, the above amplification Genes Spatial Recombinant Factor 1 / Hepatitis B Virus X-related Protein (Rsf-1 / HBXAP) is the only oncogene expressed in all ovarian cancer tissues tested.