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本文报告1990~1991年在缺碘性疾病流行区新疆托克逊县观察了一次性口服不同剂量(400、300和200mg)碘化油微囊的防治疗效及尿碘排泄。结果表明,在服药后半年和1年甲状腺肿患病率在不同剂量组均有不同程度的下降,治愈率均有不同程度的提高,但与对照组比较无论患病率还是治愈率均无显著差异(P>0.05)。不同剂量组之间服药后1月内尿碘排泄有随剂量增大相应增高的趋势(P<0.01),但至第三个月时无论是不同剂量组之间还是与对照组之间均未见显著差异(P>0.05)。从而提示,口服碘化油微囊能否作为防治缺碘性疾病的长效补碘方法,很值得商榷。
This article reports the prevention and treatment efficacy and urinary iodine excretion of oily oil microcapsules with different doses (400, 300 and 200 mg) administered orally once daily in Toksun County of Xinjiang in the endemic area of iodine deficiency diseases from 1990 to 1991. The results showed that in the six months and one year after taking the prevalence of goiter in different dose groups have decreased in varying degrees, the cure rate increased in varying degrees, but compared with the control group, no difference in the prevalence or cure rate Difference (P> 0.05). Urinary iodine excretion tended to increase with dose (P <0.01) within one month after taking different dosage groups, but no significant difference was found between the different dosage groups and the control group by the third month See significant differences (P> 0.05). It is suggested that oral iodized oil microcapsules as a long-term iodine deficiency prevention and treatment of iodine method, it is debatable.