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目的探讨联合应用丙种球蛋白与阿司匹林治疗川畸病的临床效果。方法 86例川畸病患儿,根据随机数字表法分为对照组和研究组,每组43例。对照组患儿给予阿司匹林进行治疗,研究组在对照组的基础上联合使用丙种球蛋白,对比两组患儿治疗后的临床效果、免疫球蛋白(Ig A、Ig G、Ig M)水平及治疗前后血小板、血沉、C反应蛋白的变化。结果治疗后研究组的退热时间、黏膜充血及淋巴结肿大消失时间分别为(3.58±0.65)、(2.63±0.24)、(1.53±0.26)d,对照组退热时间、黏膜充血及淋巴结肿大消失时间分别为(5.72±1.26)、(4.37±0.62)、(4.79±1.12)d,比较差异有统计学意义(P<0.05)。治疗后两组Ig A、Ig G及Ig M水平比较差异有统计学意义(P<0.05)。治疗后两组血小板、血沉、C反应蛋白均下降,且研究组下降程度显著优于对照组,比较差异有统计学意义(P<0.05)。结论丙种球蛋白联合阿司匹林治疗川畸病,能有效改善临床症状及实验室指标,降低C反应蛋白含量,控制血小板、血沉速度,值得临床推广应用。
Objective To investigate the clinical effect of combined use of gamma globulin and aspirin in the treatment of Kawasaki’s disease. Methods Totally 86 children with Kawasaki disease were divided into control group and study group according to random number table method, with 43 cases in each group. Children in the control group were given aspirin for treatment. The study group combined with gamma globulin on the basis of the control group. The clinical effects, immunoglobulin (Ig A, Ig G, Ig M) levels and treatment Before and after platelet, ESR, C-reactive protein changes. Results After treatment, the antipyretic time, mucosal congestion and disappearance of lymph nodes in the study group were (3.58 ± 0.65), (2.63 ± 0.24) and (1.53 ± 0.26) d respectively. The control group had antipyretic time, mucosal congestion and lymph node enlargement (5.72 ± 1.26), (4.37 ± 0.62) and (4.79 ± 1.12) d, respectively. The difference was statistically significant (P <0.05). After treatment, the levels of Ig A, Ig G and Ig M in the two groups were significantly different (P <0.05). After treatment, platelets, erythrocyte sedimentation rate and C-reactive protein decreased in both groups, and the degree of decrease in the study group was significantly better than that in the control group, with significant difference (P <0.05). Conclusion Gamma-globulin combined with aspirin in treatment of Kawasaki’s disease can effectively improve the clinical symptoms and laboratory parameters, reduce the C-reactive protein content, control platelet, erythrocyte sedimentation rate, worthy of clinical application.