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目的:了解并建立瑞安市高危型人乳头瘤病毒(HPV)感染的流行病学资料库并查找可能的行为危险因素。方法:收集2012年1月~2014年1月在该院妇科门诊就诊的瑞安市18岁以上妇女15 714例,采用第二代杂交捕获HPV-DNA技术(HCII)行高危型HPV检测,并收集患者的一般资料和行为危险因素。分析行为危险因素与高危型HPV感染的关系。结果:高危型HPV感染率为26.25%,18种高危型HPV亚型检测居前3位的分别是HPV 16(24.52%)、HPV 58(24.08%)和HPV 52(14.81%)。不同年龄段高危型HPV感染率不同,18岁~年龄段感染率最高,与其他年龄段比较差异有统计学意义(χ2=214.61,P<0.01)。受教育程度(初高中:OR=0.88,95%CI=0.80~0.96;大专以上:OR=0.65,95%CI=0.59~0.72)、居住地(OR=2.16,95%CI=1.82~2.97)、性伴侣人数(OR=1.36,95%CI=1.23~1.51)和使用安全套(OR=0.49,95%CI=0.43~0.55)是高危型HPV感染的独立相关因素。结论:HPV 16、HPV 58和HPV 52是瑞安市女性高危型HPV感染的主要亚型,受教育程度、居住地、性伴侣人数和是否使用安全套是高危型HPV感染的独立危险因素。
OBJECTIVE: To understand and establish an epidemiological database of high-risk human papillomavirus (HPV) infection in Rui’an City and find out possible risk factors. Methods: A total of 15 714 women aged 18 years and above in Ruian City from January 2012 to January 2014 were collected. The second-generation hybridization was used to detect high-risk HPV genotypes by HPV-DNA technology (HCII) General patient information and behavioral risk factors. To analyze the relationship between behavioral risk factors and high-risk HPV infection. Results: The prevalence of high-risk HPV was 26.25%. Among the 18 high-risk HPV subtypes, HPV 16 (24.52%), HPV 58 (24.08%) and HPV 52 (14.81%) were detected in the top 3 cases. The infection rate of high-risk HPV in different age groups was different. The infection rate was the highest in 18-year-old age group, and the difference was statistically significant compared with other age groups (χ2 = 214.61, P <0.01). (OR = 0.88, 95% CI = 0.80 ~ 0.96; college or above: OR = 0.65, 95% CI = 0.59 ~ 0.72) (OR = 1.36, 95% CI = 1.23-1.51) and condom use (OR = 0.49, 95% CI = 0.43-0.55) were independent risk factors for high-risk HPV infection. Conclusion: HPV 16, HPV 58 and HPV 52 are the major subtypes of women with high-risk HPV infection in Ruian. The educational level, place of residence, number of sexual partners and condom use are independent risk factors for HPV infection.