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目的总结本院收治13例鼻窦炎、鼻息肉病例,从送检标本中回顾性分析鼻窦炎与真菌寄植关系,以及临床与病理形态学特点。方法鼻腔手术标本用10%中性福尔马林固定,石蜡包埋,切片3μm作常规HE染色,特殊染色用PAS法和六胺银法染色。结果 13例中检出毛霉菌10例,毛霉菌+曲菌3例。结论真菌感染属机体免疫功能减退,全身消耗性疾病,代谢性疾病或长期使用皮质激素,广谱抗生素以及免疫抑制剂等致病。本组13例均以反复出现鼻塞、流脓涕及间歇性头晕、头痛等症状,以鼻窦炎求诊。尽管病程长达1个月至2年间,并无全身性感染或其它不适症状。考虑本组病例先有慢性鼻炎或鼻窦炎的感染,致鼻腔抵抗力下降,使真菌长驱直入,寄植在狭窄的鼻腔内,与周围组织无感染关系,病理形态学应与真菌性鼻窦炎相鉴别。
Objective To summarize 13 cases of sinusitis and nasal polyps treated in our hospital. The relationship between sinusitis and fungal implantation was retrospectively analyzed and the clinical and pathological features were retrospectively analyzed. Methods The nasal cavity specimens were fixed with 10% neutral formalin, embedded in paraffin and stained with 3 μm sections for routine HE staining. Special staining was performed by PAS method and hexamine silver staining. Results Among the 13 cases, 10 cases were detected with Mucor and 3 cases with Mucor and Aspergillus. Conclusions Fungal infection is caused by immune dysfunction, systemic wasting disease, metabolic diseases or long-term use of corticosteroids, broad-spectrum antibiotics and immunosuppressive agents. The group of 13 patients were repeated nasal congestion, purulent nasal discharge and intermittent dizziness, headache and other symptoms, sinusitis treatment. Although the duration of up to 1 month to 2 years, there is no systemic infection or other symptoms. Consider this group of patients with chronic rhinitis or sinusitis infection, nasal resistance decreased, so that the fungus drive straight into the narrow nasal cavity, and the surrounding tissue infection, pathological morphology should be differentiated from fungal sinusitis .