目的:观察他汀类药物对急性缺血性脑卒中(AIS)患者外周血内皮祖细胞(EPC)数量及迁移能力的影响。方法: 15例发病1周内的AIS患者,给予阿托伐他汀20 mg·d~(-1),治疗4周,用药前及用药后每周分别检测外周血EPC数量及迁移能力;9名健康对照者于入组前及第2、4周随访。结果:阿托伐他汀治疗第2周开始EPC数量逐渐增多,且第3和第4周增多较为显著(P<0.05);EPC的迁移能力在治疗第2和第3周显著提高(P<0.05),而第4周则有下降的趋势。EPC数量及迁移能力的变化与低密度脂蛋白的下降无显著相关性。结论:他汀类药物可能提高AIS患者外周血EPC的数量及迁移能力。 Objective: To observe the effects of statins on the number of EPC and the migration ability of peripheral blood in patients with acute ischemic stroke (AIS). Methods: Fifteen patients with AIS within 1 week of onset were given 20 mg · d -1 of atorvastatin for 4 weeks. Before and after treatment, the number of peripheral blood EPC and migration ability were measured respectively. Nine Healthy controls were followed up before and at weeks 2 and 4. Results: At the beginning of the second week of atorvastatin treatment, the number of EPCs gradually increased and increased significantly at the third and fourth weeks (P <0.05). EPC migration was significantly increased at the second and third weeks of treatment (P <0.05 ), While the fourth week there is a downward trend. There was no significant correlation between changes of EPC number and migration ability and the decline of low density lipoprotein. Conclusion: Statins may increase the number of EPCs and their migration ability in peripheral blood of AIS patients.