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目的探讨尼莫地平联合局部亚低温对颅脑外伤术后脑血管痉挛的防治作用。方法将颅脑外伤手术患者按入院后手术先后顺序分为对照组、治疗1组(术中生理盐水冲洗,术后静脉应用尼莫地平及局部亚低温)、治疗2组(术中尼莫地平冲洗,术后静脉应用尼莫地平及术后局部亚低温治疗)。术后第1、3、7、15天检测手术侧大脑中动脉平均血流速度。结果各组手术侧大脑中动脉平均血流速度比较,差异均有统计学意义。结论尼莫地平联合局部亚低温对颅脑外伤术后脑血管痉挛疗效显著。
Objective To investigate the preventive and therapeutic effects of nimodipine combined with local mild hypothermia on cerebral vasospasm after craniocerebral trauma. Methods According to the sequence of admission surgery, the patients undergoing craniocerebral trauma surgery were divided into control group, treatment group 1 (intraoperative saline flushing, postoperative intravenous nimodipine and local mild hypothermia) and treatment of 2 groups (nimodipine Rinse, postoperative intravenous nimodipine and postoperative local mild hypothermia). On the 1st, 3rd, 7th and 15th days, mean blood flow velocity of the middle cerebral artery was detected. Results The mean blood flow velocity of the middle cerebral artery in each group was statistically significant. Conclusion Nimodipine combined with local mild hypothermia has a significant effect on cerebral vasospasm after craniocerebral injury.