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目的：研究急性脑外伤后大鼠脑神经节苷脂含量的变化。方法：选取Ｗｉｓｔａｒ大鼠３６只，落体撞击法造成左顶脑挫裂伤，于伤后４、１２和２４小时测定脂结合唾液酸含量和神经节苷脂组分的相对百分比值变化。结果：急性脑外伤后大鼠脑组织中脂结合唾液酸含量随时间呈明显下降趋势。神经节苷脂组分的变化以ＧＤ３的持续下降及ＧＭ１的增加最为显著，而且受损２４小时后除ＧＤ１ａ外其余几种神经节苷脂含量均较受损１２小时后有显著降低。结论：急性脑外伤后脑内有自我调节机制来增加ＧＭ１的合成，但是这种自我调节是有限的，因此，建议早期使用神经节苷脂治疗急性脑外伤。
Objective: To study the change of ganglioside content in rat brain after acute traumatic brain injury. Methods: Thirty-six Wistar rats were selected. The left upper cerebral contusion was induced by falling body collision. The relative percentages of lipid-bound sialic acid and ganglioside were determined at 4, 12 and 24 hours after injury. Results: The contents of lipid-bound sialic acid in the brain tissue of rats with acute traumatic brain injury decreased significantly with time. The change of ganglioside components was the most significant with the decrease of GD3 and the increase of GM1, and the levels of the other gangliosides except GD1a were significantly lower after 12 hours of injury than those of the other gangliosides after 24 hours of injury. CONCLUSIONS: There is a self-regulatory mechanism in the brain to increase GM1 synthesis after acute traumatic brain injury, but this self-regulation is limited. Therefore, it is advisable to use gangliosides in the early stage to treat acute traumatic brain injury.