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结直肠腺癌发病率已持续40年高居不下,每年发现的15000名结直肠癌病人中有一半死亡,此病病因不明。虽发现肿瘤与病毒感染的关系已75年,但病毒对结肠癌的致病性尚未证实,如证实人乳头瘤病毒(HPV)与结肠癌有关,对此病诊断和治疗有一定的帮助。病人和方法:筛选103个病理解剖标本,其中正常组织30例,管泡状腺瘤30例,癌组织标本43例(30例为侵入性癌,13例原位癌),用免疫组化技术检测HPV相关蛋白抗原,然后再对
The incidence of colorectal adenocarcinoma has persisted for 40 years, and half of the 15,000 colorectal cancer patients found each year die. The cause of this disease is unknown. Although the relationship between tumor and virus infection has been discovered for 75 years, the pathogenicity of the virus to colon cancer has not yet been confirmed. If it is confirmed that human papillomavirus (HPV) is related to colon cancer, the diagnosis and treatment of this disease will be helpful. Patients and Methods: 103 pathological anatomical specimens were screened, including 30 normal tissues, 30 tuberculous adenomas, and 43 cancerous tissues (30 invasive and 13 in situ), using immunohistochemical techniques. Detection of HPV-related protein antigens, and then