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Background It has been reported that elevated serum lipoprotein (α)[ Lp(α)] increased cardiovascular risk. However, whether this effect is independent of serum low-density lipoprotein (LDL) remains controversial. Methods One hundred and seventy-nine acute coronary syndrome patients with desirable low-density lipoprotein level( < 2.59 mmol/L), were divided into lipoprotein (α) elevated group ( 70 cases) and lipoprotein (α) normal group (109 patients). Successful percutaneous coronary intervention (PCI) were performed before discharge. After 6-month follow-up, the adverse events of death, myocardial infarction, heart failure, progression of coronary lesions and in-stent stenosis were evaluated. Results There was higher rate of adverse events in the lipoprotein (α) elevated group than in the normal group (25.7% vs 8.3%, P = 0.001). By logistic regression analysis, odds ratio of elevated serum lipoprotein (α) was 3.846 (95% CI 1.615,9.157, P = 0.002). Conclusion Elevated serum lipoprotein (α) was associated with poor prognosis of acute coronary syndrome patients with desirable low-density lipoprotein level.
Background It has been reported that elevated serum lipoprotein (α) [Lp (α)] increased cardiovascular risk. However, whether this effect is independent of serum low-density lipoprotein (LDL) remains controversial. Methods One hundred and seventy-nine acute coronary Syndrome patients with desirable low-density lipoprotein level (<2.59 mmol / L) were divided into lipoprotein (α) elevated group (70 cases) and lipoprotein (α) normal group After 6-month follow-up, the adverse events of death, myocardial infarction, heart failure, progression of coronary lesions and in-stent stenosis were evaluated. Results There was higher rate of adverse events in the lipoprotein (α) By logistic regression analysis, the odds ratio of elevated serum lipoprotein (a) was 3.846 (95% CI 1.615, 9.157, P = 0.002). Conclusion Elevated ratio of elevated serum lipoprotein (a) was 3.846 serum lipopr otein (α) was associated with poor prognosis of acute coronary syndrome patients with desirable low-density lipoprotein level.