大黄素(emodin)具有抗炎、抗肿瘤、免疫调节等多种药理作用,同时大黄素也能抑制血管平滑肌细胞的增殖。国内外的多项研究都已证实大黄素能明显抑制血管平滑肌细胞的增殖,抑制细胞的迁移,促进细胞凋亡,并从多个方面对其进行了相关机制的探讨。同时,结合临床的转化性研究和应用探索也已展开。现就大黄素抑制血管平滑肌细胞增殖的研究进展做一综述。 Emodin (emodin) has anti-inflammatory, anti-tumor, immune regulation and other pharmacological effects, while emodin can inhibit the proliferation of vascular smooth muscle cells. Many studies both at home and abroad have proved that emodin can significantly inhibit the proliferation of vascular smooth muscle cells, inhibit cell migration and promote apoptosis, and from several aspects of its mechanism. At the same time, combined with clinical research and application of transformation has also been launched. Erythromycin inhibition of vascular smooth muscle cell proliferation research is reviewed.