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目的 :应用本实验室建立的短寿ＤＮＡ损伤剂Ｎ -甲基 -Ｎ′-硝基 -Ｎ -亚硝基胍 (ＭＮＮＧ)引起非洲绿猴肾Ｖｅｒｏ细胞基因组ＤＮＡ不稳定的应激体系模型 ,以诱导细胞发生非定标性突变的同样条件观察细胞表面受体和细胞内丝裂原激活的蛋白激酶 (ＭＡＰＫ)的激活状况 ,以探索导
OBJECTIVE: To establish a model of stress genomic DNA destabilization in African green monkey kidney Vero cells induced by N-methyl-N’-nitro-N-nitrosoguanidine (MNNG), a short- The activation of cell surface receptor and intracellular mitogen-activated protein kinase (MAPK) was observed under the same conditions to induce non-scaling mutation in cells,