近十余年来我们对暴发型流行性脑脊髓膜炎(简称暴脑)及中毒型痢疾(简称毒痢)采用以654—2为主的综合疗法,取得了显著的疗效。暴脑的病死率由过去的60％降至14.4％。毒痢由20—30％降至1.2％。疗效的提高进而发现微循环障碍在发病学上的重要意义。近来通过临床实践又进而发现微循环障碍在不少疾病的发病机理上起重要作用,总结如下: 通过对暴脑和毒痢的细致临床观察及实验 In the past decade or so, we have achieved remarkable results in the treatment of fulminant epidemic meningitis (referred to as the “brain”) and poisoning dysentery (referred to as poisoning dysentery) using 654-2-based combination therapy. The fatality rate of juvenile brain dropped from 60% in the past to 14.4%. Poison dysentery decreased from 20-30% to 1.2%. Increased efficacy in turn has led to the discovery that microcirculation disorders are clinically significant. Recently, through clinical practice and then found that microcirculation disorders play an important role in the pathogenesis of many diseases, summarized as follows: Through detailed clinical observation and experimental