论文部分内容阅读
大规模孕妇血清甲胎蛋白(下称a-FP)的普查计划为羊膜穿刺标本提供了新的一类项目。凭借于羊水乙酰胆硷酯酶(下称AchE)活性的测定,以及“快速贴瓶细胞”的实验,就可肯定或排除胎儿是否为无脑儿等神经管缺损症(NTD症),问题在于是否也应当对羊水中的胎儿细胞进行核型分析。由于在血清a-FP升高的孕妇中,胎儿异常的发生率要比未经筛选的孕妇高的多,故可根据孕妇血清中a-FP含量的异常升高来确定羊膜穿刺的对象。并可在测定羊水a-FP浓
Large-scale maternal serum alpha-fetoprotein (a-FP) census program provides a new category of amniocentesis specimens. With the determination of amniotic fluid acetylcholinesterase (hereinafter referred to as AchE) activity, and the “rapid labeling of cells” experiment, whether or not the fetus is a neural tube defects (NTD disorder) such as brainless children can be affirmed or excluded, the problem is Whether karyotyping of fetal cells in amniotic fluid should also be performed. As the incidence of fetal abnormalities in pregnant women with elevated serum a-FP is much higher than that of unselected pregnant women, the target of amniocentesis can be determined on the basis of abnormally elevated a-FP levels in the serum of pregnant women. And determination of amniotic fluid a-FP concentration