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为研究聚维酮碘药膜治疗念珠菌阴道炎的疗效和安全性,以聚维酮碘栓作阳性对照,进行部分随机单盲,多中心平行对照及部分开放试验。两药分别阴道给药,聚维酮碘药膜每天100mg,连续7天,聚维酮碘栓每天200mg,连续7天。停药后5～7天内和停药月经后复查。结果表朋,随机对照试验组聚维酮碘药膜治疗近期治愈率74.3％,有效率91.4％,远期治愈率62.9％,有效率84.3％;对照组聚维酮碘栓治疗近期治愈率71.4％,有效率85.7％,远期治愈率61.4％,有效率81.4％,两种药物疗效比较,经统计学处理,差异无显著性意义(P>0.05)。开放试验组聚维酮碘药膜治疗近期治愈率75.0％,有效率82.5％,远期治愈率65.0％,有效率80.0％。提示聚维酮碘药膜治疗念珠菌阴道炎有效,用药剂量小,无明显不良反应。
In order to study the efficacy and safety of Povidone iodine membrane in the treatment of Candida vaginitis, Povidone-iodine suppository was used as a positive control, and some randomized single-blind, multicenter parallel controls and some open tests were performed. Two drugs were vaginal administration, povidone iodine film 100mg daily for 7 days, povidone-iodine suppository 200mg daily for 7 days. After stopping 5 to 7 days and withdrawal after menstruation review. Results Table friends, randomized controlled trials Povidone iodine membrane treatment of the recent cure rate of 74.3%, the effective rate of 91.4%, the long-term cure rate of 62.9%, the effective rate of 84.3%; the control group povidone iodine suppository cure rate of 71.4 %, The effective rate was 85.7%, the long-term cure rate was 61.4% and the effective rate was 81.4%. There was no significant difference between the two drugs after statistical treatment (P> 0.05). Open experimental group Povidone iodine membrane treatment of the recent cure rate of 75.0%, the effective rate of 82.5%, long-term cure rate of 65.0%, the effective rate of 80.0%. Tip Povidone iodine membrane treatment of Candida vaginitis effective dose of small, no significant adverse reactions.