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环氧合酶 - 2 (COX- 2 )与抗凋亡信号有关 ,可能是肿瘤化疗中调节凋亡的一个指标。研究结果表明 ,短时间暴露于 PMA(3- phorbol 1 2 - myristate 1 3-acetate) ,可激活蛋白激酶 C(PKC) ,取消丝裂霉素C(MMC)诱导凋亡所致的 SAF(safingol)上调 ,恢复PKCα的活性 ;PKC的激活需 COX
Cyclooxygenase-2 (COX-2) is associated with anti-apoptotic signaling and may be an indicator of apoptosis in chemotherapy. The results showed that short time exposure to 3 - phorbol 1 2 - myristate 1 3 - acetate could activate protein kinase C (PKC) and abolish SAF induced by mitomycin C (MMC) ) Upregulation, restore PKCα activity; PKC activation need COX