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目的探讨马来酸曲美布汀对结肠镜检查患者和结肠镜操作的影响。方法将72例接受结肠镜检查的患者随机分为两组,各36例。治疗组于结肠镜检查前3 d开始服马来酸曲美布汀片100 mg/次,3次/d,至检查当日停服;对照组不服用此药物。观察两组患者在结肠镜检查过程中的腹痛、肠痉挛程度及肠道清洁程度,记录结肠镜到达回盲部时间。结果①腹痛评分:治疗组为1.7±0.6,对照组为2.2±0.8,治疗组腹痛程度明显低于对照组(P<0.05)。②肠痉挛评分:治疗组为1.9±0.6,对照组为2.4±0.8,治疗组肠痉挛程度明显低于对照组(P<0.05)。③肠道清洁率:治疗组为91.7%,对照组为75.0%,治疗组肠道清洁程度明显优于对照组(P<0.05)。④结肠镜到达回盲部时间:治疗组为11.9±3.7 min,对照组为15.7±4.3 min,治疗组结肠镜到达回盲部时间明显短于对照组(P<0.05)。结论马来酸曲美布汀可减轻结肠镜检查患者的腹痛、肠痉挛程度,改善肠道清洁程度,缩短检查时间,减轻患者痛苦,有利于内镜医师操作和完成检查。
Objective To investigate the effect of trimebutine maleate on colonoscopy and colonoscopy. Methods A total of 72 patients undergoing colonoscopy were randomly divided into two groups of 36 patients. The treatment group began trimebutine maleate tablets 100 mg / time, 3 times / d 3 days before colonoscopy to stop taking the same day; the control group did not take this drug. Observe the abdominal pain, intestinal spasm and intestinal cleanness in the two groups during colonoscopy, and record the time of colonoscopy reaching the ileocecal part. Results ① abdominal pain score: the treatment group was 1.7 ± 0.6, the control group was 2.2 ± 0.8, the treatment group abdominal pain was significantly lower than the control group (P <0.05). Intestinal spasm score: the treatment group was 1.9 ± 0.6, the control group was 2.4 ± 0.8, the treatment group intestinal spasticity was significantly lower than the control group (P <0.05). (3) Intestinal tract cleansing rate was 91.7% in the treatment group and 75.0% in the control group, and the intestine cleanliness in the treatment group was significantly better than that in the control group (P <0.05). Colonoscopy reached the ileocecal part of the time: the treatment group was 11.9 ± 3.7 min, the control group was 15.7 ± 4.3 min, the treatment group colonoscopy reached the ileocecal part was significantly shorter than the control group (P <0.05). Conclusion Trimebutine maleate can reduce the abdominal pain and intestinal spasm in colonoscopy patients, improve the intestinal cleanliness, shorten the examination time and relieve the suffering of patients, which is good for endoscopic operation and examination.