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A simple and direct route for double C–C bond formation by copper-catalyzed Meerwein carboarylation process has been developed. In the presence of Cu I(5 mol%), tert-butyl nitrite and anilines, a wide variety of N-arylacrylamides underwent tandem Meerwein arylation/C–H cyclization to produce pharmaceutically important 3-benzyl-3-alkyloxindole in moderate to good yield.
A simple and direct route for double C-C bond formation by copper-catalyzed Meerwein carboarylation process has been developed. In the presence of Cu I (5 mol%), tert-butyl nitrite and anilines, a wide variety of N-arylacrylamides underwent tandem Meerwein arylation / C-H cyclization to produce pharmaceutically important 3-benzyl-3-alkyloxindole in moderate to good yield.