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目的:观察盐酸甲氧明对剖宫产腰麻患者低血压的防治作用。方法选择180例腰麻下拟行剖宫产的患者,年龄18~40岁,ASA玉~Ⅱ级,随机分为6组(n=30)院A组在给予腰麻药物前后均未给任何药物,B组在给予腰麻药时肌注盐酸甲氧明0.1 mg/kg,C组在给予腰麻药后出现低血压时静注盐酸甲氧明0.05 mg/kg,D、E、F组分别在A、B、C组基础上预输注胶体8 ml/kg。经上述处理后,若血压仍明显偏低,则给予适量的麻黄碱。记录基础值和腰麻后5、10、15、20、25、30 min时的收缩压、舒张压、心率及麻黄碱总用量、恶心呕吐的发生率。结果与基础值比较,在腰麻后各时点,E组血压及心率平稳(>0.05),其余各组均出现血压下降、心率增快(<0.05)。与A组比较,其余各组麻黄碱总用量减少、恶心呕吐发生率降低(<0.05);与E组比较,B、C、D组麻黄碱总用量增多、恶心呕吐发生率增高(0.05) in blood pressure and heart rate of group E, and blood pressure was lower, heart rate was higher ( <0.05) in the other groups at each time point after lumbar anesthesia. Compared to group A, total dose of ephedrine and the incidence of nausea and vomiting in the other groups were both lower ( <0.05);compared to group E, total dose of ephedrine and the incidence of nausea and vomiting in group B, C and D were both higher ( <0.05). Conclusion During cesarean section with lumbar anesthesia, previously intramuscular injection of methoxamine hydrochloride and accompanying with the right amount of col oidal solution to improve blood volume can prevent and cure hypotension during surgery, and low the incidence of nausea and vomiting induced by hypotension.