近20年来,帕金森病(Parkinson’s disease,PD)研究领域发生了一些新进展,尤其在突触核蛋白病理、非运动症状和前驱症状[1]方面,因此有必要重新定义PD。2015年8月,国际运动障碍疾病协会正式发布了PD的临床诊断新标准(表1),以下将对该新诊断标准进行解读[2]。首要的问题是:为什么要制定PD诊断标准?尽管之前临床上PD的诊断一直沿用英国脑库于1997年发布的诊断标 In recent 20 years, there have been some new developments in the field of Parkinson’s disease (PD), especially in synuclein pathology, non-motor symptoms and prodromal symptoms [1], so it is necessary to redefine PD. In August 2015, the International Association of Sports Disorders and Diseases officially released a new clinical diagnostic criteria for PD (Table 1). The following new diagnostic criteria will be read [2]. The first question is: Why PD diagnostic criteria? Although the clinical diagnosis of PD has been using the British brain bank issued in 1997 diagnostic criteria