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目的探讨血清超敏C-反应蛋白(hs-CRP)、甲胎蛋白(AFP)、癌胚抗原(CEA)、铁蛋白(Fer)联合检测鉴别诊断肝癌与肝脏良性疾病的应用价值。方法选择42例肝癌患者为肝癌组,40例肝脏良性疾病患者为良性组,42例健康体检者为健康组。检测三组hs-CRP、AFP、CEA、Fer水平,比较三种检测方案对肝癌的诊断效果。结果肝癌组hs-CRP、AFP、CEA、Fer水平均高于良性组和健康组,差异有统计学意义(P<0.05)。四种指标联合检测灵敏度为94.35%(117/124),准确度为80.49%(66/82),均高于另两种检测。结论血清蛋白联合检测可提高诊断灵敏度和准确度,值得临床推广应用。
Objective To investigate the value of serum hs-CRP, AFP, CEA and Fer for the differential diagnosis of benign liver cancer and liver diseases. Methods Forty-two patients with hepatocellular carcinoma (HCC) were selected as the hepatocellular carcinoma (HCC) group. Forty patients with benign liver disease were selected as benign group and 42 healthy subjects as healthy group. The levels of hs-CRP, AFP, CEA and Fer were detected in three groups, and the diagnostic results of three test methods were compared. Results The levels of hs-CRP, AFP, CEA and Fer in HCC were significantly higher than those in benign and healthy controls (P <0.05). The combined detection sensitivity of the four indexes was 94.35% (117/124) and the accuracy was 80.49% (66/82), which were higher than the other two tests. Conclusion Combined detection of serum proteins can improve the diagnostic sensitivity and accuracy, worthy of clinical application.