硝硫氰胺是一种很有前途的治疗血吸虫病新药。但少数病例在毒性剂量作用下对循环也有一定影响,表现为血压降低,心率减慢及频发早搏,心电图S—T段升高,T波平坦或倒置。由于心电图的变化常在心肌细胞动作电位上出现反映,因此我们观察了硝硫氰胺对蟾蜍心室肌细胞动作电位的影响。 Nitrocyanamine is a promising new drug for the treatment of schistosomiasis. However, a small number of cases under the influence of toxic doses on the cycle also have some impact, manifested as blood pressure, heart rate slowed and frequent premature beats, ECG S-T segment increased, T wave flat or inverted. Because electrocardiogram changes are often reflected in the action potential of cardiomyocytes, we observed the effect of nitrites on the action potentials of ventricular myocytes in Toads.