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目的头孢菌素类药物与其他药物联用导致不良反应的情况。方法选取予以头孢菌素类药物联合其他药物产生不良反应的患者116例作为观察对象,对比联用前后不良反应的发生情况。结果应用头孢菌素类药物联合其他药物导致不良反应涉及:消化系统、神经系统、肾功能损伤、肝功能损伤及过敏反应等。联合用药后不良反应发生率高于联合用药前,差异有统计学意义(P<0.05)。结论临床应用头孢菌素类药物联合其他药物会导致不良反应增加,故为减少不良反应的发生,应尽量避免联合用药。
The purpose of cephalosporins and other drugs lead to adverse reactions. Methods A total of 116 patients with adverse reactions of cephalosporins combined with other drugs were selected as the observation objects to compare the incidence of adverse reactions before and after combination. Results The application of cephalosporins combined with other drugs lead to adverse reactions involving: digestive system, nervous system, renal damage, liver damage and allergic reactions. The incidence of adverse reactions after combination therapy was higher than that before combination therapy, the difference was statistically significant (P <0.05). Conclusion Clinical cephalosporins combined with other drugs will lead to increased adverse reactions, it is to reduce the incidence of adverse reactions should be avoided as far as possible combined with medication.