近20年来,皮肤代谢及药理学的科学探讨增多。在过去几年,注意力特别集中于婴儿外用药,其作用与成人相比有质和量的不同。在1972年前,已知动物血六氯酚水平如果长期维持在1μg/ml 就可以发生脑损伤,以含3%六氯酚液体皂给新生儿洗澡,3～5天后血中浓度达到显著的水平。外用含有6.6%六氯酚的婴儿扑粉后引起婴儿死亡。因此必须进一步了解药物作用,不仅限于被认为靶器官的皮肤,而且更应注意通过皮肤的渗透及血药浓度,身体其他组织对药物及其代谢产物的亲和力;皮肤本身作用于药物而产生的代谢物。此外婴儿体表面积与体重的比率 Over the past 20 years, the skin metabolism and pharmacological science to explore more. In the past few years, special attention has been paid to the use of external medicines for infants, whose effects are qualitatively and quantitatively different from those of adults. Prior to 1972, it was known that blood levels of animal blood hexachlorophenol can be brain damage if maintained at 1 μg / ml for long periods of time, bathing newborns with 3% hexachlorophenol liquid soap and achieving significant blood levels after 3 to 5 days Level. Infants were dumped after topical application of 6.6% hexachlorophenol. Therefore, we must further understand the role of drugs, is not limited to be considered as the target organ of the skin, but also should pay attention to through the skin penetration and plasma concentration, the body’s other tissues on the drug and its metabolites affinity; skin itself acting on drugs and metabolism Things. In addition, the ratio of body surface area to body weight