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目的研究尿素、乌拉坦、维生素 Ｃ、地塞米松对兔血红细胞渗透抵抗性的影响，为临床用药提供一定的理论依据。方法实验分对照组、维生素Ｃ组、尿素组、维生素Ｃ＋尿素组、维生素Ｃ＋乌拉坦组、尿素＋乌拉坦＋维生素Ｃ组、尿素＋乌拉坦＋地塞米松组。观察维生素Ｃ、尿素及二者同时作用，维生素Ｃ、乌拉坦及二者同时作用对红细胞渗透脆性的影响以及地塞米松和维生素Ｃ抑制尿素和乌拉坦所致的红细胞渗透脆性增加的影响。结果维生素Ｃ组与对照组红细胞渗透脆性有显著差异（Ｐ< ０．０１），尿素＋乌拉坦组与尿素＋乌拉坦＋维生素Ｃ组红细胞渗透脆性有显著差异（Ｐ<０．０１），尿素＋乌拉坦组与尿素＋乌拉坦＋地塞米松组红细胞渗透脆性有显著差异（Ｐ<０．０１）。结论维生素Ｃ单独作用增加红细胞渗透抵抗性，维生素Ｃ和地塞米松具有抑制尿素和乌拉坦所致红细胞渗透脆性增加的作用。
Objective To study the effects of urea, urethane, vitamin C and dexamethasone on rabbit erythrocyte osmotic resistance and to provide a theoretical basis for clinical use. Methods The experiment was divided into control group, vitamin C group, urea group, vitamin C + urea group, vitamin C + urethane group, urea + urethane + vitamin C group, urea + urethane + dexamethasone group. To observe the effect of vitamin C, urea and their simultaneous action on the erythrocyte osmotic fragility and the effect of dexamethasone and vitamin C on the increase of erythrocyte osmotic fragility induced by urea and urethane. Results There was a significant difference in erythrocyte osmotic fragility between vitamin C group and control group (P <0.01). There was significant difference in erythrocyte osmotic fragility between urea + urethane group and urea + urethane + vitamin C group (P <0.01) There was a significant difference of erythrocyte osmotic fragility between urea + urethane group and dexamethasone group (P <0.01). Conclusion Vitamin C alone can increase erythrocyte osmotic resistance. Vitamin C and dexamethasone can inhibit the increase of erythrocyte infiltration fragility caused by urea and urethane.