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目的观察米非司酮单用与联用对稽留流产患者血浆、蜕膜组织米非司酮浓度及流产结局的影响。方法 47例稽留流产患者随机分2组,分别口服单方或复方米非司酮片,用高效液相色谱法测定血浆和子宫蜕膜组织米非司酮浓度。记录流产效果、出血量和流产时间。结果血浆和蜕膜组织的米非司酮浓度,2组间差异有统计学意义(P<0.05)。平均流产时间和出血量,复方组明显低于单方组(P<0.05)。结论米非司酮剂量与血浆和蜕膜组织浓度呈正比;与双炔失碳酯合用可缩短流产时间,减少出血量。
Objective To observe the effects of mifepristone alone and in combination on mifepristone concentration and abortion outcome in patients with abortion and abortion. Methods 47 cases of missed abortion patients were randomly divided into two groups, respectively, oral administration of either mifepristone tablets or tablets, high performance liquid chromatography determination of plasma and uterine decidual tissue mifepristone concentration. Record abortion effects, bleeding and abortion time. Results Plasma and decidual tissue concentrations of mifepristone, the difference between the two groups was statistically significant (P <0.05). Mean abortion time and bleeding volume in the compound group were significantly lower than those in the unilateral group (P <0.05). Conclusion The dose of mifepristone is directly proportional to the concentration of plasma and decidua. Combining with anordrin can shorten the time of abortion and reduce the amount of bleeding.