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目的观察纳洛酮对内毒素血症大鼠肠系膜微循环变化的影响。方法经股静脉注射内毒素5mg kg)建立实验模型,将60只大鼠随机分为对照组、内毒素损伤组和纳络酮干预组,每组20只,分为个亚组,分别观察完成注射后1、2、4、6h微循环变化。结果内毒素损伤后大鼠肠系膜微循环发生显著变化,纳洛酮干预后这种变化明显减轻。内毒素损伤组、纳洛酮干预组大鼠肠系膜微循环的血流速度等指标与对照组有差异。结论纳洛酮可改善内毒素引起的肠系膜微循环障碍。
Objective To observe the effect of naloxone on the changes of mesenteric microcirculation in endotoxemic rats. Methods Endotoxin injection via the femoral vein 5mg kg) to establish an experimental model, 60 rats were randomly divided into control group, endotoxin injury group and naloxone intervention group, each group of 20, divided into subgroups, respectively, were observed Microcirculation changes at 1, 2, 4, 6h after injection. Results The rat mesenteric microcirculation changed markedly after endotoxin injury, and the change was significantly reduced after naloxone intervention. Endotoxin injury group, naloxone intervention group mesenteric microcirculation of blood flow and other indicators and the control group differences. Conclusion Naloxone can improve endotoxin-induced mesenteric microcirculation.