基因突变引起基因序列碱基组成变化作为肿瘤发生的一个重要原因已为大家所熟知。与突变不同,表观遗传学改变并不发生基因序列的变化,但它所产生的后果却是相同的,均导致基因表达的异常。目前的表观遗传学研究主要集中在DNA甲基化、组蛋白修饰、染色质结构变化三大方面。其中DNA甲基化作为表观遗传学的一个重要内容最受重视,特别在肿瘤研究领域。目前 Gene mutation causes changes in the base sequence of the gene sequence as an important cause of the tumor has been well-known. Unlike mutations, epigenetic changes do not occur in the gene sequence changes, but the consequences it produces are the same, leading to abnormal gene expression. The current epigenetic studies focused on DNA methylation, histone modification, chromatin structure changes in three areas. DNA methylation is one of the most important aspects of epigenetics, especially in the field of oncology. Currently