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目的对两种三联疗法治疗幽门螺杆菌感染(HP)胃溃疡的效果进行比较和探讨。方法 46例幽门螺杆菌相关性胃溃疡患者分为对照组和观察组,每组23例。对照组应用奥美拉唑、阿莫西林与甲硝唑进行治疗,观察组应用奥美拉唑、阿莫西林与克拉霉素进行治疗,对采用不同三联疗法治疗的患者的临床疗效及幽门螺杆菌根除率进行比较。结果经治疗4周后,对照组有4例治愈,12例有效,7例无效,总有效率为69.56%;观察组有9例治愈,13例有效,1例无效,总有效率为95.65%,组间比较差异具有统计学意义(P<0.05)。对照组HP根除率为60.87%(14/23),观察组HP根除率为86.97%(20/23),差异具有统计学意义(P<0.05)。结论应用奥美拉唑+阿莫西林+克拉霉素三联疗法治疗幽门螺杆菌相关性胃溃疡,其治疗效果好于奥美拉唑+阿莫西林+甲硝唑,可提高HP根除率,促进溃疡面愈合,值得临床借鉴与推广。
Objective To compare the effects of two triple therapy on Helicobacter pylori (HP) gastric ulcer. Methods 46 cases of Helicobacter pylori-associated gastric ulcer patients were divided into control group and observation group, 23 cases in each group. The patients in the control group were treated with omeprazole, amoxicillin and metronidazole. The observation group was treated with omeprazole, amoxicillin and clarithromycin. The clinical efficacy and pyloric screw in patients treated with different triple therapy Mycorrhizal eradication rates were compared. Results After 4 weeks of treatment, 4 cases were cured in the control group, 12 cases were effective, 7 cases were ineffective and the total effective rate was 69.56%. In the observation group, 9 cases were cured, 13 cases were effective and 1 case was ineffective. The total effective rate was 95.65% , The difference between the groups was statistically significant (P <0.05). The control group HP eradication rate was 60.87% (14/23), the observation group HP eradication rate was 86.97% (20/23), the difference was statistically significant (P <0.05). Conclusion Omeprazole + amoxicillin + clarithromycin triple therapy in the treatment of Helicobacter pylori associated gastric ulcer, the treatment effect is better than omeprazole + amoxicillin + metronidazole, can improve the HP eradication rate and promote Ulcer surface healing, it is worth clinical reference and promotion.