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目的:对糖尿病肾病早期诊断中尿微量蛋白和Ⅳ型胶原检测的应用进行研究。方法:选自我院自2007年3月-2009年4月期间收治的糖尿病患者50例以及50例健康人,对以上所有患者以及健康人群采用免疫比浊法来测定尿微量蛋白,进行尿RBP、TRF的测定以及尿IV-C的测定,对mALB/Cr,RBP/Cr,TRF/Cr以及IV-C进行比较。结果:根健康组mALB/Cr为1.91mmol/L,RBP/Cr为2.15mmol/L,TRF/Cr为1.79mmol/L以及IV-C为45.78mmol/L;无肾病组患者mALB/Cr为5.98mmol/L,RBP/Cr为15.31mmol/L,TRF/Cr为5.95mmol/L以及IV-C为91.34mmol/L;初期肾病组mALB/Cr为27.31mmol/L,RBP/Cr为29.21mmol/L,TRF/Cr为19.89mmol/L以及IV-C为149.21mmol/L;临床肾病组mALB/Cr为53.26mmol/L,RBP/Cr为44.89mmol/L,TRF/Cr为36.41mmol/L以及IV-C为261.65mmol/L。结论:尿微量蛋白和Ⅳ型胶原检测对糖尿病肾病早期诊断是有帮助的,值得临床深究推广。
Objective: To study the application of urinary microalbumin and type Ⅳ collagen in the early diagnosis of diabetic nephropathy. Methods: Fifty patients with diabetes mellitus and 50 healthy people who were admitted to our hospital from March 2007 to April 2009 were enrolled in this study. Urine microalbumin was measured by immunoturbidimetry in all the above patients and healthy people. Urinary RBP, Measurement of TRF and determination of urinary IV-C compared mALB / Cr, RBP / Cr, TRF / Cr and IV-C. Results: The mALB / Cr of root health group was 1.91mmol / L, RBP / Cr was 2.15mmol / L, TRF / Cr was 1.79mmol / L and IV-C was 45.78mmol / mmol / L, RBP / Cr was 15.31mmol / L, TRF / Cr was 5.95mmol / L and IV-C was 91.34mmol / L. The initial renal disease group mALB / Cr was 27.31mmol / L, RBP / Cr was 29.21mmol / L, TRF / Cr 19.89mmol / L and IV-C 149.21mmol / L; clinical nephropathy group mALB / Cr 53.26mmol / L, RBP / Cr 44.89mmol / L, TRF / Cr 36.41mmol / L and IV-C was 261.65 mmol / L. Conclusion: The detection of urinary microalbumin and type Ⅳ collagen is helpful for the early diagnosis of diabetic nephropathy, and it is worth further investigation in clinic.