Objective: To explore the potential antidepressant mechanism of Wenyang Jieyu Granules with multiple targets and components based on network pharmacology, and to verify the cAMP pathway and animal experimental results. Methods: The active components of Aconitum, Guizhi, Glycyrrhiza uralensis, Wumei, Jujube and Ginger in Wenyang Jieyu Granules were searched and screened by TCM System Pharmacology Analysis Platform (TCMSP). Using the Swiss database to predict its target, and then through the UniProt database to query the target corresponding genes; with the use of Gene Cards、OMIM database query depression related target Point and gene mapping to get the potential target of Wenyang Jieyu granule antidepressant. using Cytoscape, String software to plot the “wenyangjieyu granule-active component-potential action target-depression” network and “protein interaction network ”, and using David database for GO functional enrichment analysis and KEGG pathway enrichment analysis to predict the action mechanism of wenyangjieyu granule in the treatment of depression and verify it with some previous relevant experimental results. Autodock software was used to perform molecular docking experiments on selected components and targets. Results: The topology analysis is effective there are 47 core components of depression, and 40 potential key targets are SLC6A2, SHBG, ACHE, NR3C1, ESR1. they are involved in many biological processes, such as neurotransmitter receptor conduction, ammonium ion binding, postsynaptic neurotransmitter receptor activity, G protein-coupled neurotransmitter receptor activity. they play an antidepressant effect through brain tissue nerve activity ligand-receptor interaction signaling pathway, cAMP, PI3K-Akt, MAPK signaling pathway, ErbB signaling pathway, etc. At the same time, the results of molecular docking show that the core components have good binding force to the key targets. Conclusion: Wenyang Jieyu granule. The active components of the anti-depressant effect are mediated by multiple signaling pathways and multiple targets.