β受体阻滞剂的发现和临床应用是20世纪药物治疗学上的重大突破。早在1984年,β受体阻滞剂就被推荐为高血压治疗用药,并在临床实践中广为应用。根据多年来治疗高血压的大量循证医学证据,β受体阻滞剂已成为治疗高血压的经典药物,一直是多个权威指南推荐的首选抗高血压药物之一。然而,近年来一些研究结果的发表却导致β受体阻滞剂降压地位的下降,甚至使其在高血压治疗中的一线地位遭受质疑和 The discovery and clinical application of β-blockers is a major breakthrough in the 20th century in the field of medical therapeutics. As early as 1984, beta blockers were recommended for the treatment of hypertension, and widely used in clinical practice. Based on the large evidence-based medical evidence of treatment for hypertension over the years, beta-blockers have become a classic drug for the treatment of hypertension and have been one of the preferred anti-hypertensive drugs recommended by several authoritative guidelines. However, the publication of some research results in recent years has led to the decline of antihypertensive status of β-blockers and even their question of the first-line status in the treatment of hypertension.